Search results for " Elderly patients"

showing 10 items of 22 documents

In-hospital death and adverse clinical events in elderly patients according to disease clustering: The REPOSI study

2010

OBJECTIVE: The aim of the study was to recognize clusters of diseases among hospitalized elderly and to identify groups of patients at risk of in-hospital death and adverse clinical events according to disease clustering. METHOD: This was a cross-sectional study conducted in 38 internal medicine and geriatric wards in Italy participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The subjects were 1,332 inpatients aged 65 years or older. Clusters of diseases (i.e., two or more co-occurrent diseases) were identified using the odds ratios (OR) for the associations between pairs of conditions, followed by cluster analysis. Logistic regression models were used to evaluate the …

MaleAgingDisease clustersPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaHospital unitDiseaseHospital mortalitydisease clusteringLogistic regressionNO80 and overMedicineCluster AnalysisHumansHospital MortalityAgedAged 80 and overIn hospital deathMedical Errorsbusiness.industryClinical eventsAged; Aged 80 and over; Cluster Analysis; Female; Hospital Mortality; Humans; Italy; Male; Medical ErrorsREPOSIIn-hospital death; elderly patients; disease clustering; REPOSIIn-hospital deathOdds ratioSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatricheelderly patientItalyFemaleGeriatrics and Gerontologybusinesspatients at risk of in-hospital death; adverse clinical events according to disease clustering
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Hepatitis C virus (HCV) infection in elderly patients: A multicenter Italian cross-sectional study

2009

medicine.medical_specialtyHepatologybusiness.industryCross-sectional studyHepatitis C virusGastroenterologyHEPATITIS C VIRUS INFECTIONCHRONIC HEPATITISmedicine.disease_causeHEPATITIS C VIRUS INFECTION; ELDERLY PATIENTS; CHRONIC HEPATITISInternal medicineELDERLY PATIENTSMedicinebusiness
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Risk factors for hospital readmission of elderly patients

2012

Background: The aim of this study was to identify which factors were associated with a risk of hospital readmission within 3 months after discharge of a sample of elderly patients admitted to internal medicine and geriatric wards. Methods: Of the 1178 patients aged 65 years or more and discharged from one of the 66 wards of the 'Registry Politerapie SIMI (REPOSI)' during 2010, 766 were followed up by phone interview 3 months after discharge and were included in this analysis. Univariate and multivariate logistic regression models were used to evaluate the association of several variables with rehospitalization within 3 months from discharge. Results: Nineteen percent of patients were readmi…

MaleSettore MED/09 - Medicina InternaTime FactorsRisk factors; internal medicine; Geriatric patient; hospital admissionLogistic regressionElderly; Hospital readmission; Internal medicine and geriatric wards; Risk factorsElderlyInternal medicine and geriatric wards80 and overElderly; Hospital readmission; Internal medicine and geriatric wards; Risk factors; Aged; Aged 80 and over; Female; Geriatrics; Hospital Departments; Humans; Internal Medicine; Male; Patient Readmission; Risk Factors; Time Factors; Internal MedicineMedical diagnosisAged Aged; 80 and over Female Geriatrics Hospital Departments Humans Internal Medicine Male Patient Readmission; statistics /&/ numerical data Risk Factors Time FactorsAged 80 and overGeriatricsUnivariate analysisvascular diseaseHospital readmissionSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheAgeing; readmissionstatistics /&/ numerical dataHospital DepartmentFemaleliver diseaseHumanmedicine.medical_specialtyTime FactorHospital DepartmentsMEDLINEHospital readmission Internal medicine and geriatric wards Risk factors Elderlyelderly patientsPatient ReadmissionNOInternal MedicinemedicineHumansRegistry Politerapie SIMI (REPOSI)Adverse effectAgedreadmissionbusiness.industryRisk FactorUnivariatemedicine.diseaseComorbidityHospital readmission; elderly patients; Registry Politerapie SIMI (REPOSI); vascular disease; liver diseaseHospital readmission; Internal medicine and geriatric wards; Risk factors; Elderlyelderly; hospital readmission; risk factors; internal medicine and geriatric wardsInternal medicine and geriatric wardAgeingGeriatric patienthospital admissionRisk factorsGeriatricsEmergency medicinebusinessGeriatricEuropean Journal of Internal Medicine
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Weekly Cisplatin and Volumetric-Modulated Arc Therapy With Simultaneous Integrated Boost for Radical Treatment of Advanced Cervical Cancer in Elderly…

2016

Background: To evaluate the feasibility and clinical preliminary results of weekly cisplatin and volumetric-modulated arc therapy to the pelvis with simultaneous integrated boost to macroscopic disease in a cohort of elderly patients. Materials and Methods: Inclusion criteria of this prospective study were age ≥70 years, Karnofsky performance status 70 to 100, locally advanced histologically proven squamous cervical carcinoma, and patients unable to undergo brachytherapy. Radiation doses prescribed were 66 Gy to the macroscopic disease and 54 Gy to the pelvic nodes in 30 fractions. Weekly cisplatin dose was 40 mg/mq. Results: A total of 30 patients were recruited. Median follow-up was 32 mo…

Simultaneous integrated boostMalemedicine.medical_specialtyCancer ResearchBrachytherapyUterine Cervical NeoplasmsVMATelderly patients030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineWeekly cisplatinmedicineArc therapyHumansAgedCervical cancerRadical treatmentAged 80 and overbusiness.industryRadiotherapy DosageArticlesmedicine.diseaseVolumetric modulated arc therapyCombined Modality TherapySurgeryOncology030220 oncology & carcinogenesisCarcinoma Squamous CellVMAT; advanced cervical cancer; elderly patients; gynecological malignanciesFemaleadvanced cervical cancer; elderly patients; gynecological malignancies; VMAT; Oncology; Cancer ResearchRadiologyDose Fractionation RadiationLymph NodesRadiotherapy Intensity-ModulatedCisplatinbusinessgynecological malignanciesadvanced cervical cancer
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Practice guidelines for the treatment of hepatitis C: recommendations from an AISF/SIMIT/SIMAST Expert Opinion Meeting.

2010

It is increasingly clear that a tailored therapeutic approach to patients with hepatitis C virus infection is needed. Success rates in difficult to treat and low-responsive hepatitis C virus patients are not completely satisfactory, and there is the need to optimise treatment duration and intensity in patients with the highest likelihood of response. In addition, the management of special patient categories originally excluded from phase III registration trials needs to be critically re-evaluated. This article reports the recommendations for the treatment of hepatitis C virus infection on an individual basis, drafted by experts of three scientific societies.

Liver CirrhosisANTIVIRAL TREATMENTHuman immunodeficiency virus (HIV)HIV InfectionsHepacivirusANTIVIRAL THERAPY; PEGYLATED INTERFERON-ALPHA-2B; LIVER-TRANSPLANTATION; PEGINTERFERON ALPHA-2A; HIV-INFECTED PATIENTS; VIRUS-COINFECTED PATIENTS; RAPID VIROLOGICAL RESPONSEAntiviral therapymedicine.disease_causeGastroenterologyPolyethylene GlycolsHBVguidelinesAcute hepatitisChronic hepatitisSettore MED/12 - Gastroenterologialiver transplantationGastroenterologyAntiviral therapyHepatitis CVIRUS-COINFECTED PATIENTSLIVER-TRANSPLANTATIONHepatitis CRecombinant Proteinsacute hepatitis; antiviral therapy; chronic hepatitis; cirrhosis; elderly patients; hbv; hcv; hdv; hiv; liver transplantationCLINICAL PRACTICE GUIDELINESCirrhosisHCVDrug Therapy CombinationAntiviral therapy Acute hepatitis Chronic hepatitisCirrhosis Elderly patients HBV HCV HDV HIV Liver transplantationElderly patientAcute hepatitiAcute hepatitismedicine.medical_specialtyGenotypePEGINTERFERON ALPHA-2AAlpha interferonHIV-INFECTED PATIENTSInterferon alpha-2CHRONIC HEPATITIS CAntiviral AgentsHepatitis B ChronicChronic hepatitisInternal medicineHDVDrug Resistance ViralRibavirinmedicineHumansPEGYLATED INTERFERON-ALPHA-2BCirrhosiHepatologybusiness.industrySettore MED/09 - MEDICINA INTERNAInterferon-alphaHIVHepatitis C Chronicmedicine.diseaseElderly patientsFamily medicineExpert opinionAntiviral therapy; Acute hepatitis; Chronic hepatitis; Cirrhosis; Elderly patients; HBV; HCV; HDV; HIV; liver transplantationChronic hepatitiRAPID VIROLOGICAL RESPONSEbusinessCHRONIC HEPATITIS C; ANTIVIRAL TREATMENT; CLINICAL PRACTICE GUIDELINES
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Statins for the primary prevention of cardiovascular events in elderly patients: a picture from clinical practice without strong evidence from clinic…

2008

general practiceClinical Trials as TopicCardiovascular DiseasesStatins; primary prevention; elderly patients; general practiceIncidenceprimary preventionStatinsHumansHydroxymethylglutaryl-CoA Reductase Inhibitorselderly patientsUnited StatesAged
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What are the benefits of a minimally invasive approach in frail octogenarian patients undergoing aortic valve replacement?

2016

Not available

Transcatheter aortic valve implantationScience & TechnologyCardiac & Cardiovascular SystemsGeriatrics & GerontologySURGERYAortic valve stenosiAortic valve stenosis1102 Cardiovascular Medicine And HaematologyElderly patientsCardiovascular System & HematologyMinimally invasive surgerySymposium: Transcatheter aortic valve implantationCardiovascular System & CardiologyAortic valve stenosis; Elderly patients; Minimally invasive surgery; Transcatheter aortic valve implantation; Cardiology and Cardiovascular Medicine; Geriatrics and GerontologyGeriatrics and GerontologyCardiology and Cardiovascular MedicineElderly patientLife Sciences & Biomedicine
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Adverse Clinical Events and Mortality During Hospitalization and 3 Months After Discharge in Cognitively Impaired Elderly Patients

2012

BACKGROUND: Controversial findings are reported on hospital outcome in cognitively impaired patients. The aim of this study was to explore mortality risk according to cognitive status during hospitalization and after 3 months in elderly patients. METHODS: Sixty-six internal medicine and geriatric wards in Italy participated in the "Registry Politerapie SIMI (REPOSI)" during 2010. Of the 1,380 in-patients, aged 65 and older enrolled, 1,201 were included. Cognition was evaluated with the Short Blessed Test (SBT). Logistic regression was used to evaluate the association of questionable and impaired cognition (according to SBT cutoff points) with mortality during hospitalization and at follow-u…

GerontologyMaleARDSTime FactorsSettore MED/09 - Medicina InternaActivities of Daily Living Aged Aged; 80 and over Cognition Disorders; diagnosis/mortality Female Geriatric Assessment; methods Hospital Mortality Hospitalization; statistics /&/ numerical data Humans Intelligence Tests Italy; epidemiology Logistic Models Male Odds Ratio Patient Discharge; statistics /&/ numerical data Risk Assessment; methods Risk Factors Severity of Illness Index Time Factorsdiagnosis/mortalitycognitively impaired patients; Registry Politerapie SIMI (REPOSI); Elderly patients;Logistic regressionSeverity of Illness IndexDementia; agingRisk FactorsActivities of Daily Living80 and overOdds RatioHospital MortalityAged 80 and overIntelligence TestsAdverse clinical eventsCognitionSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatrichePatient Dischargestatistics /&/ numerical dataHospitalizationItalyFemaleepidemiologyElderly patientmedicine.medical_specialtyelderly patientsRisk AssessmentOddsmethodsNOInternal medicinemedicineDementiaHumansRegistry Politerapie SIMI (REPOSI)Adverse effectGeriatric Assessmentcognitive functionAgedbusiness.industryagingOdds ratiocognitively impaired patientmedicine.diseasemortalityConfidence intervalhospital admissionLogistic ModelsAdverse clinical events; elderly patients; cognitive function; mortality; hospital admissionDementiaGeriatrics and GerontologybusinessCognition Disorders
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Eight-point compass rose underlay technique in 72 consecutive elderly patients with large incisional hernia

2011

Summary Background Repair of incisional hernia (IH) in the elderly is a challenge for the surgeon. Primary closure is preferable but is not always possible because of high recurrence rates of IH repaired without a prosthesis and/or possible respiratory and cardiovascular complications due to extreme tension of the margins. We report our experience with underlay mesh placement in elderly patients with large IH. Methods A total of 72 patients from January 2003 to December 2009 underwent IH repair involving placement of an intraperitoneal Gore® DualMesh® prosthesis. The prosthesis was first anchored at eight points in a compass rose pattern using a Gore® suture passer and then firmly secured t…

medicine.medical_specialtyIncisional herniamedicine.medical_treatmentHigh-risk elderly patientAdhesion (medicine)lcsh:GeriatricsProsthesisePTFE meshTension-free techniqueAbdominal wallLarge ventral herniaSuture (anatomy)PneumoperitoneumePTFE mesh; High-risk elderly patients; Large ventral hernia; Suture passer; Tension-free techniquemedicineLaparoscopyhigh-risk elderly patientsSuture passermedicine.diagnostic_testbusiness.industrymedicine.diseaseSurgeryDissectionlcsh:RC952-954.6Settore MED/18 - Chirurgia Generalemedicine.anatomical_structureGeriatrics and Gerontologybusiness
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Cisplatin-based first-line treatment of elderly patients with advanced non-small-cell lung cancer: Joint analysis of MILES-3 and MILES-4 phase III tr…

2018

Purpose To test the efficacy of adding cisplatin to first-line treatment for elderly patients with advanced non–small-cell lung cancer (NSCLC) within a combined analysis of two parallel phase III trials, MILES-3 and MILES-4. Patients and Methods Patients with advanced NSCLC who were older than age 70 years with Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned to gemcitabine or pemetrexed, without or with cisplatin. In each trial, 382 events were required to detect a hazard ratio (HR) of death of 0.75, with 80% power and two-tailed α of .05. Trials were closed prematurely because of slow accrual, but the joint database allowed us to analyze the efficacy of …

0301 basic medicineOncologyMaleCancer Researchmedicine.medical_specialtyPhases of clinical researchKaplan-Meier EstimatePemetrexedDeoxycytidine03 medical and health sciences0302 clinical medicineInternal medicineCarcinoma Non-Small-Cell Lungmedicineadvanced non small cell lung cancer (NSCLC) elderly patients cisplatin MILES 3 MILES 4Progression-free survivalLung cancerSurvival rateAgedAged 80 and overAntineoplastic Combined Chemotherapy ProtocolPerformance statusbusiness.industrymedicine.diseaseGemcitabineLung Neoplasm030104 developmental biologyPemetrexedTreatment OutcomeOncologyResponse Evaluation Criteria in Solid Tumors030220 oncology & carcinogenesisQuality of LifeFemaleCisplatinbusinessmedicine.drugHuman
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